The Spaniard's loss has opened the door for Carlos Alcaraz and Casper Ruud to make a run at No.1.
The American is in it to win it in Queens.
The Croatian dismantled red-hot Liudmila Samsonova to reach her first US Open quarterfinal.
The Russian's loss opens the door for three players.
The Aussie shook up the draw by knocking off top-seeded Daniil Medvedev on Sunday night in New York.
The Aussie has turned a corner and genuinely believes he can win a major.
The Spaniard had a rough season but hope springs eternal.