The Russian's loss opens the door for three players.
The Aussie shook up the draw by knocking off top-seeded Daniil Medvedev on Sunday night in New York.
The Aussie has turned a corner and genuinely believes he can win a major.
The Spaniard had a rough season but hope springs eternal.
The American shares a side of Kyrgios that the public doesn't always take note of.
Nick Kyrgios is 3-1 lifetime vs. US Open champion Daniil Medvedev.
The American speaks to the media after her last US Open match.