The 19-year-old has reached at least the third round at three straight majors.
The Russian is 1-5 against Nadal and has lost both his Grand Slam finals against him.
Victoria Azarenka extended her hand, but Marta Kostyuk wasn't willing to shake.
"We're both big hitters and we're both going to be trying to be the aggressor. I look forward to it," Madison Keys said of facing Coco Gauff.
"When when the crowd gets involved, that's what it can get to you," Ajla Tomljanovic said of her Friday night showdown vs. Serena Williams.
"American Son" will tell the story of Michael Chang's immigrant family and his remarkable Roland Garros title run at age 17.
The American was 0-3 against Osaka and had never taken a set from her.
