"You don't retire Saturday morning," world No. 1 said of Murray's Saturday withdrawal from the US Open.
World No. 1 loves the energy, but not the noise of Arthur Ashe Stadium.
“I feel like my game always rises a lot in the bigger events,” said ninth seed.
The 35-year-old Spaniard falls in the first round at a major for the first time in over 12 years.
The Canadian will face Russia's Daniil Medvedeve in the first round on Monday.
The tournament announced the launch of its new "Full Bloom" campaign for 2018.
The Russian wild card will face No.2-seeded Simona Halep in her opener.