By Nick Georgandis

Remember two years ago when Andy Roddick started to fade a little bit - falling to (gasp) No. 11 in the rankings - and suddenly there were no American men in the Top 10 anymore?

Kinda feels like we were a little spoiled now, doesn't it?

On Tuesday, John Isner lost in the first round of the Rogers Cup, guaranteeing that the 6-foot-10-inch drink of water will fall to at least No. 22 in the world come next Monday's ATP rankings.

That means no American male will be ranked in the Top 20 for the first time since ... well, ever.

Isner, Mardy Fish and Sam Querrey had managed to keep the Top 20 streak alive after Roddick fell out of it permanently in 2012, but only by the skin of their teeth in recent months.

Plagued by injuries, Fish last appeared in the Top 20 on Aug. 13, 2012. Querrey has bounced between No. 19 and No. 23 since the beginning of this year befor dropping to 26th last week.

That left Isner, who climbed as high as ninth in 2012 and was still No. 15 this past March before slowly sinking. The fact that he reached the Rogers Cup semifinals a year ago did not bode well entering this week's play, and his loss Tuesday guaranteed his exit from the elite. It might be a long stay for Isner outside the Top 20 if he doesn't bounce back in a hurry. In 2012 he won Winston-Salem (250 points) and reached the third round of the US Open (90 points), giving him plenty to defend in the weeks ahead.