By Chris Oddo

(March 18, 2013) -- Current World No. 1 and five-time Sony Open champion Serena Williams will return to action this week in Miami. Here's a breakdown of a star-studded draw that features all but one top 20 player (Sam Stosur withdrew due to injury).

Read: Miami Men's Draw Preview, Will Murray Bring the Heat in Miami?

Serena Williams' Quarter:

Serena has had ample to time to rest after a tumultuous start to the season that saw her injuries sabotage her quest for a 16th career Grand Slam at the Australian Open. Miami has always been one of her favorite places to play, as her five titles attests, but she has only played once since 2009, losing in the quarterfinals last year to Caroline Wozniacki.

Serena has a tricky draw that could see her face Yanina Wickmayer in the third round, Dominika Cibulkova or Lucie Safarova in the round of 16, and Li Na or Caroline Wozniacki in the quarterfinals. After a bye in the first round, Williams may get former top tenner Flavia Pennetta in her first match.

But if her fitness is good, she's obviously the favorite to make it through.

Pick: Serena

Early Match to Watch: Li Na and Kiki Bertens, Possible second-rounder. It will be interesting to see what type of form the World No. 5 is in after being out of action since the Australian Open due to an ankle injury.

Agnieszka Radwanska's Quarter:

Radwanska, the current World No. 4, will start her title defense in so-so form. She hasn't had a bad year, but it hasn't been great either, and she'll no doubt feel some pressure as the defending champion in Miami.

Radwanska could face a very challenging third-round matchup with Mona Barthel, and if she navigates her way into the round of 16, she could face the winner of what will be a highly anticipated third-round match between Venus Williams and Sloane Stephens if the seeds hold.

In the lower half of this quarter, Marion Bartoli could face a wildcard Andrea Petkovic if the German can get by Bojana Jovanovski of Serbia in the first round, and Petra Kvitova could face the tricky Peng Shuai in the second round.

With Bartoli and Kvitova battling for a round of 16 spot, and Radwanska facing multiple challenges in her section, this quarter could be the most difficult to pick.

Pick: Bartoli

Early Match to Watch: Petkovic-Bartoli, possibly in round two; Venus Williams and Kimiko Date-Krumm in a possible round two veteran matchup.

Sharapova's Quarter

The World No. 2 has reached the finals in Miami in back-to-back years, and from the looks of her draw, she's got a very good chance to do it again this year. The next two highest-seeded player in her quarter, 14th-seeded Maria Kirilenko or 8th-seeded Sara Errani could be Sharapova's toughest competition in her quarter, and she crushed each player in her run to the Indian Wells title last week. Ana Ivanovic and Ekaterina Makarova could also make some noise in this section, as well as unseeded Svetlana Kuznetsova, Sabine Lisicki, or maybe even Urszula Radwanska.

Pick: Sharapova

Early Match to Watch: Kuznetsova-Makarova, possible 2nd-rounder.

Azarenka's Quarter:

Azarenka is the figurative wildcard in this draw, because it's not really clear if the foot problems that forced her out of the Indian Wells draw are going to either hamper her performance or force her to withdraw from Miami.

Normally the undefeated and a two-time Miami champion would be our pick to make it out of this quarter, but with she's got a tricky draw from the get-go, and we're not so sure that she's even going to play, let alone compete for a title.

If she does go she could face 17-year-old American wildcard Madison Keys in the second round in a match that American enthusiasts will be drooling over. Can Keys do to Azarenka what Sloane Stephens almost did in Australia? Likely not, but that match will likely tell us what we can expect from the Belarusian for the remainder of the draw.

If she looks fit, she's the odds-on favorite to pass through a quarter that features 6th-seeded Angelique Kerber (possible QF opponent), 15th-seeded Roberta Vinci (possible R16 opponent) and Nadia Petrova (possible QF opponent).

When it's all said and done, Azarenka's biggest challenge, prior to a possible quarterfinal with Kerber, will be to get off the court quickly so that her foot's healing process continues to progress.

Pick: Kerber

Early Match to Watch: Laura Robson vs. Camila Giorgi, first round, Madison Keys vs. Azarenka, possible second-rounder

Semifinals: Williams d. Bartoli, Sharapova d. Kerber

Finals: Williams d. Sharapova

(Photo Credit: AP)