By Chris Oddo | Thursday, August 21, 2014

Top-seeded Novak Djokovic will face a difficult draw at the 2014 US Open, as the draw revealed that he could face top-ranked American John Isner in the round of 16 and potentially Andy Murray or Jo-Wilfried Tsonga in the quarterfinals.

Video: Djokovic Appears on the Late Show with David Letterman

The 2011 champion will open his bid for a second US Open title with Diego Schwartzman of Argentina, and could face his first seeded opponent in the third round in the form of Spain’s Guillermo Garcia-Lopez.

Since Wimbledon, Djokovic has struggled, going 2-2 with two round of 16 defeats in Toronto and Cincinnati.

In the bottom half of the draw Roger Federer could be headed for a quarterfinal matchup with rising Bulgarian Grigor Dimitrov.

Federer will open his bid for a sixth US Open title with Marinko Matosevic of Australia, and will face either Sam Groth of Australia or Albert Ramos-Vinolas in the second round. The highest seed Federer could face before the quarterfinals is 15th-seeded Fabio Fognini of Italy.

Potential men’s semifinals, if the seeds hold, at the US Open are: Djokovic-Wawrinka and Federer-Ferrer.

Stay tuned for a full draw preview on Friday.

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